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Antimicrobial            

Copper Clinical Trials

sampling surfaces in tghe copper-equipped bathroom at Selly Oak

Clinical trials are under way at hospitals around the world, providing a variety of ward types (geriatric, intensive care and general medical), local clinical strains of organisms and national healthcare settings to put copper and copper alloys to the test. The first results, from the Selly Oak trial, show a 90-100% reduction in contamination on copper vs standard surfaces, leading trial leader Prof. Tom Elliott to conclude:

“The findings of a 90 to 100% killing of those organisms, even after a busy day on a medical ward with items being touched by numerous people, is remarkable. So it may well offer us another mechanism for trying to defeat the spread of infection."

These findings have since been supported by results from other trials, as reported below, and hospitals around the world are starting to specify antimicrobial copper touch surfaces as an additional weapon in the fight against infection.

Selly Oak, UK

A Copper Clinical Trial commenced at the end of 2007 at Selly Oak Hospital, part of the University Hospital Birmingham NHS Trust, to assess copper’s ability to reduce reservoirs of infection and therefore reducing the risk of infection when it is directly integrated in a hospital environment.

The first results were presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in Washington, 28th October 2008. The study found that, when tested, items made from copper had 90-100% fewer micro-organisms on them, compared with the same items made out of standard materials.

In the test ward, frequently touched surfaces were identified and replaced with copper-containing items including: door handles, push plates, sink taps, grab rails, dressing trolleys, over-bed tables, toilet seats and light switches. These items were used and evaluated over a period of 18 months, in order to observe the effects on environmental microbial loads.

The study is being carried out jointly by the University Hospital Birmingham and Aston University, under the leadership of Professors Tom Elliott and Peter Lambert who have considerable expertise and an international reputation regarding the interaction between bacteria and surfaces in the clinical environment.

On the latest status of the trial, Prof Elliott explains:

“The findings of a 90 to 100% killing of those organisms, even after a busy day on a medical ward with items being touched by numerous people, is remarkable. So it may well offer us another mechanism for trying to defeat the spread of infection."

Role of copper in reducing hospital environment contamination web link
A.L. Casey, D. Adams, T.J. Karpanen, P.A. Lambert, B.D. Cookson, P. Nightingale, L. Miruszenko, R. Shillam, P. Christian and T.S.J. Elliott, J Hosp Infect (2009), doi:10.1016/j.jhin.2009.08.018.
The environment may act as a reservoir for pathogens that cause healthcare-associated infections (HCAIs). Approaches to reducing environmental microbial contamination in addition to cleaning are thus worthy of consideration. Copper is well recognised as having antimicrobial activity but this property has until now not been applied to the clinical setting.

ICAAC poster: Copper for Preventing Microbial Environmental Contamination, A L Casey, P A Lambert, L Miruszenko, T S J Elliott. October 2008.

See the slide show below for some of the copper and copper alloy products being used in the test ward.

Videos and Images

Trial results and their significance play video
Prof Tom Elliott, UHB NHS Trust
4.5 mins, 8.8 MB

Copper products - practical aspects play video
Mark Tur, CDA Technical Consultant
4.5 mins, 10.8 MB

Installed products
With links to suppliers.

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Partners

Copper Development Association is proud to be working with the following forward thinking companies who are providing antimicrobial materials, products and services. Details of available products can be found in the product catalogue.

Copper and copper alloy suppliers

Aalco

Copper alloy stockholders

Aurubis UK Ltd

 

Cold rolled copper alloy strip

Antimicrobial champion: Brian Middleton

Blackheath Tube

 

Copper and copper alloy tube

Antimicrobial champion: Alan Garner

B Mason and Sons Ltd

Cold rolled copper alloy strip

Antimicrobial chamption: Sallie-Ann Eaton

Bolton MKM Ltd

Brass extrusions

Cole & Swallow Ltd

Copper alloy tube

Columbia Metals Ltd

Specialist copper alloy stockholders

Johnson Matthey Metal Joining

Brazing and metal joining

KME UK

 

Semi-finished copper and copper alloy products

Antimicrobial champion: Paul Senior

Luvata

Metal fabrication, component manufacturing and related engineering and design services

W & S Allely Ltd

Copper alloy stockholders

Product suppliers/service providers

Frank Allart and Co Ltd

Architectural hardware (vertical/horizontal push plates lever handle back plates, kick plates)

Allgood plc

Architectural hardware (lever/pull handles)

Armack Chemicals Ltd

Metal finishing

Assa Abloy

Architectural hardware (cubicle door locks, thumbturn & release sets, pull handles)

Barwood Products (Staff) Ltd

 

Grab rails, hinged support arms & shower seats.

Antimicrobial champion: Geoff Croft

Doyle & Tratt Products Ltd

 

Copper light switches/switched sockets

Antimicrobial champion: Andrew Wilson

Dudley Industries

Washroom dispensing systems (soap, towels, aprons etc)

Huntleigh Technology PLC Group

Hospital beds

IBP Conex Ltd

Plumbing fittings (basin wastes, bottle traps, sink wastes)

Antimicrobial champion: Colin Taylor

Johnson Diversey UK Ltd

 

Commercial cleaning and hygiene solutions

Antimicrobial champion: Pete Gilbert

Laidlaw Solutions Ltd

Architectural hardware

McDonald Diecasting Ltd

 

Copper levers and light pulls.

Antimicrobial champion: Alan Carter

Mercury Composites

 

Supplier of cold sprayable metal coatings/castings, bed tables

Antimicrobial champion: Terry Gould

Nottingham Rehab Supplies

 

Suppliers of daily living aids (grab rails/drop down rails)

Antimicrobial champion: JohnTurner

OMC Technologies

 

Cleanroom furniture (trolleys)

Antimicrobial champion: Joe Brennan

Parker Pens

Pens

Pegler Yorkshire Group Ltd

Tube fittings and valves

Rycroft Ltd

Coppersmiths/surface cladding (bedside tables)

TG Stamping and Machining Ltd

 

Components in a wide range of copper and copper alloys

Antimicrobial champion: Jon Norton

Triflow Concepts Ltd

 

Single lever mixer taps, two lever mixer taps, pillar taps, wall mounted taps

Antimicrobial champion: Alyn Mackenzie

Union Architectural Hardware

Locking hardware

Willenhall Tube and Forging Co Ltd

Tube manipulation, machining and welding processes (IV drip poles)

Wissner Bosserhoff

Hospital beds

Product/material efficacy testing

Contact

University of Southampton

Emma Goode

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USA and Chile

In the USA a three-centre Department of Defense-funded clinical trial has published findings on environmental contamination in intensive care units. This study shows that objects in closest proximity to the (immobile) patients, such as bed rails, nurse calls buttons and chairs, have the highest levels of staphylococci, meticillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). This suggests that touch surfaces in these wards serve as reservoirs that could transfer bacteria to patients, healthcare workers and visitors.

High-risk touch surfaces identified in the first phase of this trial were replaced with copper components in patient rooms designated as 'copper rooms'. Other patient rooms retained the standard components and these acted as 'control rooms'. Copper and equivalent standard components were sampled for contamination which was assessed by standard microbiological techniques.

The first results of the comparison in bioburden on installed copper and standard surfaces were pubished at the 5th Decennial International Conference on Healthcare-Associated Infections, Atlanta, March. Results confirm the Selly Oak findings ie a significant reduction in bioburden on the copper surfaces - nurse call buttons, iv drip poles, chair arms and bed rails compared to controls. In addition, neither VRE nor MRSA were detected on any of the copper surfaces.

These results are also confirmed by the Calama Hospital, Chile, trial, using the same replacement copper components, even at extremely low relative humidity. These results were presented at the 14th International Conference on Infectious Diseases, Miami, March 2010.

US trial results

Chile trial results

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Germany

In the Asklepios Clinic, Wandsbek, in Hamburg, Germany, aluminium door handles and plastic light switches in a geriatric ward and its adjacent bathrooms have been replaced by copper alloy equivalents. The patients in the control and trial wards have similar profiles.

The results generated in the first three months of the trial (May - July 2008) have focused on the total level of contamination in a 'summer' situation and, more specifically, on the MRSA bug, to reinforce the UK findings. The trial resumed later in 2008 to investigate a 'winter' scenario. Results show significant reductions in bioburden which surpassed the expectations of the investigators.

Other

In addition to the trials in the UK, Germany and the USA, testing of copper's potential to fight pathogens is also under way in South Africa and Japan.

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